Computerized provider order entry (CPOE) and clinical decision support (CDS) are widely used tools to help improve safe prescribing practices. This systematic review of 17 studies examined the impact of CPOE systems with CDS in preventing pediatric medication dosing errors. Included studies evaluated CDS tools providing dose range checks, dose calculators, and dosing frequency checks. The majority of studies reported improvements in dose error prevention with use of CPOE-CDS systems, with eight studies reporting significant reductions in dosing errors.