Health information technology has positively impacted many aspects of patient care, but technology-related errors (TREs) still threaten patient safety. Set at one pediatric hospital in Australia, this retrospective study evaluated technology-related prescribing errors associated with computerized provider order entry (CPOE) over a four-year period. One-year post-CPOE implementation, researchers found that TRE rates decreased by 40%; however, rates returned to pre-CPOE levels after four years.