Adverse drug events (ADE) are common medical errors that can lead to additional healthcare utilization and patient harm. This Cochrane review, including 15 studies with over 62,000 participants, evaluated the effectiveness of interventions to improve ADE reporting. The review found low-certainty evidence that education sessions paired with reminder cards and ADE report forms can significantly improve reporting rates. The review found uncertain or very low-certainty evidence on the effectiveness of other inventions (eg, linking to ADE reporting in the EHR, government regulations with financial incentives).