The effectiveness of integrated health information technologies across the phases of medication management: a systematic review of randomized controlled trials.
McKibbon A, Lokker C, Handler S, et al. The effectiveness of integrated health information technologies across the phases of medication management: a systematic review of randomized controlled trials. J Am Med Inform Assoc. 2012;19(1):22-30. doi:10.1136/amiajnl-2011-000304.
This systematic review identified 87 randomized controlled trials assessing the effect of information technology on various aspects of medication safety, including studies of computerized provider order entry. Although processes of care consistently improved, few studies demonstrated improvement in clinical outcomes.