Misdiagnosis in the emergency department (ED) is estimated to affect over 7 million patients each year and can lead to increased morbidity and mortality. This retrospective study conducted at one academic medical center evaluated identified diagnostic errors by comparing discordance between ED diagnosis and discharge diagnosis after hospital admission. The researchers identified a difference in diagnosis between the ED physician and the discharge diagnosis in 1 in 6 patients; these cases were associated with longer length of stay and additional diagnostic discrepancies.