Rapid assessment procedures (RAP) describe a group of methods for studying organizational processes, practices and implementation. This study used RAP to evaluate the implementation of a package of patient safety interventions in intensive care units at four academic medical centers. The RAP approach included developing evaluation questions with stakeholder input, integrating implementation science into field guides and analytic tools, using a multidisciplinary evaluation team, building trust with the sites, engaging sites in participatory data collection, rapid team analysis of data sources, and validating findings with the sites. The RAP approach identified barriers and facilitators to successful intervention implementation and produced contextually-rich information using robust methods within a short timeframe. The authors conclude that this approach is particularly useful for learning health systems because it engages stakeholders in uncovering new insights.