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High Reliability Organization (HRO) Principles and Patient Safety

Timothy Vogus, PhD; Merton Lee, PharmD, PhD; Sarah E. Mossburg, RN, PhD | February 26, 2025 
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Vogus T, Lee M, Mossburg SE. High Reliability Organization (HRO) Principles and Patient Safety. PSNet [internet]. Rockville (MD): Agency for Healthcare Research and Quality, US Department of Health and Human Services. 2025.

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Vogus T, Lee M, Mossburg SE. High Reliability Organization (HRO) Principles and Patient Safety. PSNet [internet]. Rockville (MD): Agency for Healthcare Research and Quality, US Department of Health and Human Services. 2025.

In To Err Is Human, the seminal Institute of Medicine report that drew attention to patient safety, medical error is described as arising from interactions within complex systems rather than an individual’s failings. Because most errors arise from systems, achieving better patient safety requires large-scale changes more than increased individual effort.1 The report describes a body of knowledge that proposes that although error and accidents are caused by larger scale forces, they can be avoided through organization-wide commitments, especially to “safety, high levels of redundancy in personnel and safety measures, and a strong organizational culture for continuous learning and willingness to change.”2(p57) This type of organization-wide commitment to safety describes how organizations in high-risk fields, such as aviation and nuclear power, achieve safety and have come to describe a mode of organization called high reliability organizations (HRO).2

HRO principles refer to mindful organizing focused on safety and promoted through organizational culture, as described in AHRQ’s primer on High Reliability. HRO principles have been described as having five characteristics:

  • Preoccupation with failure: Awareness of potential for failure and emergence of new threats so that absence of error does not lead to complacency
  • Reluctance to simplify interpretations: Understanding that the work of providing care is complex and dynamic and that underlying causes must be found, as opposed to surface explanations
  • Sensitivity to operations: Recognition that an individual’s work occurs in the complexity of larger operational conditions, and that those conditions can affect safety
  • Commitment to resilience: Awareness of the unpredictability of the system and its inherent risks, leading to situation assessment with the goal of identifying safety threats quickly and responding before problems cause harm
  • Deference to expertise: Understanding that expertise may reside with the person closest to the safety threat, not with the person of highest status

Despite the association of HRO principles with improved patient safety and availability of programs designed to implement HRO principles in health care, questions remain on how best to transform culture to support patient safety and how to consistently achieve high reliability performance.3,4,5,6

High Reliability Organization Principles Associated with Safety Improvements

Evidence continues to accrue on how safety interventions enable HRO principles and, in turn, safety in a variety of healthcare settings. For instance, applying HRO principles has resulted in increased patient safety via decreased medical error and improved patient identification. In a qualitative study of primary care teams, researchers found that interventions to increase medication safety corresponded to HRO principles, especially in anticipating medication error. Another study on medication safety reports on the use of a tool based on HRO principles for reducing potentially inappropriate medications and deprescribing. The authors report that use of their HRO-based tool, implemented in 38 Veterans Health Administration programs, resulted in deprescribing over 128,000 potentially inappropriate medications, with over $4 million saved. In a review of nationwide patient safety reports and root cause analyses in the Veterans Health Administration, researchers found that patient misidentification was prevalent in both inpatient and outpatient settings and that strategies based on HRO principles were used to reduce these errors, according to reporting institutions.

Beyond particular patient safety incidents like medication error or patient misidentification, an academic medical center and safety net hospital, the University of Mississippi Medical Center, described its implementation of HRO principles showing improvements in their patient quality and safety metrics of about 10% to 60% depending on the metric. Hospital leadership then set goals to build on improvements in patient quality and safety to further achieve efficiency, by applying HRO principles in operations and finance. By focusing on improving clinical documentation, care coordination and cost of care, the hospital found that high reliability contributed to decreased length of stay, higher CMS Star rankings and ultimately greater efficiency. In this study, this hospital’s application of HRO principles first to patient safety and quality and then to operations and finance shows the robustness of HRO interventions, where gains in patient safety can be realized either in specific cases, such as medication safety, or more broadly, as in hospital operations.

Challenges Associated with HRO in the Complex Environment of Health Care

Interventions based on HRO principles can vary in extent, from a limited goal such as medication safety to a broad goal like hospital operations. While the characteristics of HRO principles have inspired interventions, researchers tested a tool of HRO implementation, the High Reliability Health Care Maturity (HRHCM) model, to assess the model’s validity and its ability to differentiate the extent of HRO implementation at six Veterans Health Administration hospitals. The findings showed that the tested maturity model was valid and differentiated hospitals, but that further research is needed to elucidate how the model could guide hospitals in developing the infrastructure needed to achieve highly reliable performance. The HRHCM was also used to investigate the extent of integration of HRO principles at 46 institutions participating in the Children's Hospitals' Solutions for Patient Safety network, a network of hospitals already committed to employing HRO principles to increase patient safety. Their survey showed that 80% of hospitals reported “approaching high reliability,” with no hospitals at the first or beginning level. While these high rates of maturity in the HRHCM assessment reflect a commitment to patient safety, the survey reveals opportunities for growth. For instance, few organizations reported that high reliable safety performance was a top priority for CEOs, who acknowledge safety is a priority but delegate responsibility. Prior studies have shown that direct CEO-level accountability is associated with gains in safety.7

In a follow-up study on hospitals in the Children's Hospitals' Solutions for Patient Safety network, researchers assessed survey results to test the correlation between patient harm as measured by the Serious Harm Index and components of high reliability, such as culture of safety, leadership or robust process improvement and an overall high reliability metric the researchers developed. This single study found that only culture of safety was associated with decreases in the Serious Harm Index, which could suggest that some elements of HRO principles have more immediate impact on patient safety than others. However, a growing body of research has consistently found that, taken together, high reliability principles are associated with lower levels of medication errors and patient falls across multiple studies of hospital nursing units.8 For example, one study found that a one-unit increase in high reliability principles (measured on a 1-to-7 scale) was associated with 25% fewer medication errors and 37% fewer patient falls.9

Prior research has found that the widespread use of care pathways that standardize care can enhance the effects of high reliability principles on medical errors (i.e., by further reducing them).10 Moreover, a qualitative study found that HRO principles were unevenly implemented and understood in a Canadian pediatric hospital. Based on interviews with hospital executives, program leaders, staff, and physicians, the study found that nurses were often the targets of HRO interventions, which due to existing hierarchies led to piecemeal implementations. They also found that while most interviewees could identify safety interventions implementing the HRO characteristics of “preoccupation with failure,” “reluctance to simplify interpretations,” and “sensitivity to operations,” the principles of “commitment to resilience” and “deference to expertise” were more limited in application. Thus, questions remain on how best to intervene to integrate all the HRO principles and on which HRO principles are most necessary for patient safety.

Broader Effects of High Reliability Organization Principles on Patient Safety

Evidence shows that HRO principles are associated with increased safety and that adopting HRO principles may impact other factors affecting the healthcare workforce. In a focus group study comparing healthcare units based on safety measure performance, researchers found that how high-performing units discussed safety was correlated with HRO principles. Similarly, another qualitative study on HRO adoption found that certain leadership skills appear to be associated with successful implementation of HRO principles. For example, a nonhierarchical leadership style supports the HRO principle of deference to experience, where expertise may lie with different people depending on context and need. Finally, a study on pursuing highly reliable performance among nurses in three Midwestern acute-care hospitals found lower rates of emotional exhaustion among RNs and lower levels of nursing unit turnover.

Conclusion

High reliability organization principles are applied to health care based on an understanding that health care delivery is inherently high-risk. HRO principles describe a mindset in which conditions are set to improve patient safety. As a mindset, HRO principles are not static, and in the complex realm of care delivery, HRO may be applied with variability to the detriment of safety.11 Organizations have been pursuing models to measure the maturity of HRO implementation. They are also directly assessing HRO principles and linking them to higher patient safety and workforce outcomes like emotional exhaustion and turnover, along with leadership approaches and organizational practices that may enhance the HRO principles and safer healthcare delivery.

References
  1. Carayon P, Schoofs Hundt A, Karsh BT, et al. Work system design for patient safety: the SEIPS model. Qual Saf Health Care. 2006;15 Suppl 1(Suppl 1):i50-i58. doi:10.1136/qshc.2005.015842. [Free full text]
  2. Committee on Quality Health Care in America, Institute of Medicine. To Err Is Human: Building a Safer Health System. Kohn KT, Corrigan JM, Donaldson MS, eds. National Academy Press; 2000. [Free full text]
  3. Myers CG, Sutcliffe KM. High reliability organising in healthcare: still a long way left to go. BMJ Qual Saf. 2022;31(12):845-848. [Free full text]
  4. Cropper DP, Harb NH, Said PA, et al. Implementation of a patient safety program at a tertiary health system: A longitudinal analysis of interventions and serious safety events. J Healthc Risk Manag. 2018;37(4):17-24. doi:10.1002/jhrm.21319
  5. Brilli RJ, McClead RE Jr, Crandall WV, et al. A comprehensive patient safety program can significantly reduce preventable harm, associated costs, and hospital mortality. J Pediatr. 2013;163(6):1638-1645. doi:10.1016/j.jpeds.2013.06.031
  6. Berry SA, Doll MC, McKinley KE, et al. ProvenCare: quality improvement model for designing highly reliable care in cardiac surgery. Qual Saf Health Care. 2009;18(5):360-368.
  7. Slessor SR, Crandall JB, Nielsen GA. Case study: getting boards on board at Allen Memorial Hospital, Iowa Health System. Jt Comm J Qual Patient Saf. 2008;34(4):221-227. [Available at]
  8. Ausserhofer D, Schubert M, Blegen M, De Geest S, Schwendimann R. Validity and reliability on three European language versions of the Safety Organizing Scale. Int J Qual Health Care. 2013;25(2):157-166. [Available at]
  9. Vogus TJ, Iacobucci D. Creating highly reliable health care: how reliability-enhancing work practices affect patient safety in hospitals. ILR Review. 2016;69(4):911-938. [Available at]
  10. Vogus TJ, Sutcliffe KM. The impact of safety organizing, trusted leadership, and care pathways on reported medication errors in hospital nursing units. Med Care. 2007;45(10):997-1002. 
  11. Rotteau L, Goldman J, Shojania KG, et al. Striving for high reliability in healthcare: a qualitative study of the implementation of a hospital safety programme. BMJ Qual Saf. 2022;31(12), 867-877.
This project was funded under contract number 75Q80119C00004 from the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health and Human Services. The authors are solely responsible for this report’s contents, findings, and conclusions, which do not necessarily represent the views of AHRQ. Readers should not interpret any statement in this report as an official position of AHRQ or of the U.S. Department of Health and Human Services. None of the authors has any affiliation or financial involvement that conflicts with the material presented in this report. View AHRQ Disclaimers
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Vogus T, Lee M, Mossburg SE. High Reliability Organization (HRO) Principles and Patient Safety. PSNet [internet]. Rockville (MD): Agency for Healthcare Research and Quality, US Department of Health and Human Services. 2025.