This study used an innovative approach to involving patients in safety efforts by using an interactive kiosk paired with the medication list from the electronic health record. When patients presented for a clinic visit, the kiosk presented their presumed medication list along with pill pictures, and patients had to indicate if they were taking the medication. This method successfully identified medication discrepancies and reduced the time spent by staff in reviewing medications. Ensuring medication reconciliation in ambulatory care has been particularly problematic for patients with low health literacy. This novel strategy may represent an effective, patient-centered approach to this problem.