Continuous vital sign monitoring can generate a large volume of alarm notifications that may not represent meaningful change in clinical status and can lead to alarm fatigue, which has become a patient safety priority. This article describes Plan-Do-Study-Act processes employed in the acute care cardiology unit of a large, urban academic medical center that resulted in a reduction in alarm notifications of 68% over 2.5 years. Patient safety was maintained as these improvements were made and reductions in alarm notifications were sustained for more than 18 months.