The COVID-19 pandemic disrupted cancer screening and diagnostic visits. This study reports the difference between observed and expected cancer rates in 2020 and 2021 in the United States. The percentage difference between the expected and observed cancer rates in 2020 was -8.6%, but largely recovered in 2021 (-0.2% difference). Recovery rates varied by patient demographics (e.g., rural location) and cancer site. A cumulative deficit of more than 127,000 patients still exists, presenting a concern for a surge of patients presenting with more advanced disease in upcoming years.