Opioid prescribing is under increased scrutiny in an effort to address opioid misuse. Examining Medicare Part D prescription trends, this report recommends that the Centers for Medicare and Medicaid Services collect more data on beneficiaries receiving high doses of opioids and the clinicians who prescribe them and advocates for increased reporting of clinicians who inappropriately prescribe opioids. An Annual Perspective discussed the opioid epidemic as a patient safety problem.