Anesthesiology made its mark early on in the quest for patient safety. Eichhorn was a part of the convergence that resulted in successful change in that specialty in the 1970s. He and Morell are well suited to be at the helm of the first anesthesia textbook on patient safety. The book opens with a recap on anesthesia’s historic involvement in achieving and sustaining safety improvements. In addition, authors provide clinical guidance on topics such as positioning and airway algorithms and the use of simulators as training environments. A variety of solutions are provided to support continued success in this highly technical area of medicine.