Nurses have a significant impact on patient safety. This integrative review of clinical practice guidelines identified 6 themes representing nursing care strategies to manage risk and prevent harm – (1) detect risk or early change, (2) act early to prevent deterioration, (3) identify and treat underlying conditions, (4) grade escalation of care, (5) provide a safe care environment, and (6) engage patient and care partners. These findings highlight the complexity of nursing work and illustrate strategies that nurse leaders can integrate into local practice to improve safe care.