In an attempt to characterize the socioeconomic impact of drug-related hospitalizations, this study examined more than 360 consecutive admissions to a cardiology service searching for drug events as a cause. Based on classifying “definite” and “probable” drug events, the rate of drug-related hospitalizations approached 6%. Admissions most frequently occurred in elderly patients and those on diuretics or digoxin. The authors conclude that although one third of the drug events were not likely preventable, the majority offered opportunity for intervention with directed educational efforts.