Patient-reported measures (PRM) can improve the diagnostic process by incorporating perspectives from patients and caregivers. In this study, researchers used human-centered design principles, information from environmental scans, and expert workgroups to create “roadmaps” for developing feasible and usable PRMs that can support diagnostic excellence. This iterative process identified seven diagnostic excellence goals that can be achieved with PRMs. Sample roadmaps (illustrating the development and implementation of the PRMs to achieve diagnostic excellence goals) are also presented.