Better understanding of the challenges faced by patients and clinicians in the diagnostic pathway can ensure development of appropriate diagnostic technologies. In this study, patients with lived experience of cardiovascular disease (CVD) and clinicians described their experiences and challenges in coming to an accurate diagnosis. Patients and clinicians described symptom interpretation, patient characteristics, patient-clinician interaction, and systemic challenges as all contributing to difficulty in getting a timely CVD diagnosis. Considerations to reduce these diagnostic challenges are presented along with ways technology can be utilized for further reductions.