The groundbreaking National Academy of Medicine report Unequal Treatment highlighted the pervasive nature of racial and ethnic disparities in United States health care. Racial and ethnic minorities experience more adverse events, including adverse drug events and hospital-acquired infections. Investigators used a pediatric global trigger tool to delineate disparities in safety events for a large, random sample of pediatric patients across 16 hospitals (4 hospitals in each US region). Latino children experienced nearly twice the rate of adverse events when compared with white children. Publicly insured children also had a higher adverse event rate. An accompanying editorial reviews study limitations and highlights the need to develop risk-prediction models for different types of adverse events.