This study examined whether a full-integration approach to a hospital merger and acquisitions (consisting of early leadership integration, rapid transition to electronic health record systems, local ownership of quality metrics, dashboards featuring system goals and actional analytics, and use of value-based and analytic-driven interventions) improved patient outcomes. Compared to the situation pre-merger, findings show that in-hospital mortality and hospital-acquired infection rates were lower, while patient satisfaction were higher after the full-integration merger.