Measuring hospital safety culture is considered a best practice supported by both the Agency for Healthcare Research and Quality (AHRQ) and the Leapfrog Group. Although the data linking positive safety culture to patient outcomes is inconclusive, establishing a strong culture of safety is considered essential to patient safety. Researchers analyzed AHRQ Survey on Patient Safety Culture data submitted by 536 hospitals from 2007 through 2014 and identified 6 large (> 400 beds) hospitals demonstrating significant improvement over time. They then conducted interviews with quality leaders from those institutions. Qualitative analysis of interview transcripts revealed common best practices across those hospitals, including systematic safety culture measurement, widespread communication of results, both leadership and frontline engagement in improvement efforts, and implementation of patient safety initiatives. A PSNet perspective discussed how to improve safety culture.