The COVID-19 pandemic led to dramatic changes in healthcare delivery and presented new challenges to safe patient care. Among patients ages 18 years and older admitted to the hospital between January 2019 and June 2020, this study found that the first surge of the COVID-19 pandemic was not associated with an increase in patient safety events (measured using the AHRQ patient safety indicators) among patients without COVID-19. Among the individual PSIs, only in-hospital falls with hip fractures were significantly higher during the first surge of the pandemic.