The COVID-19 pandemic impacted nearly every aspect of healthcare delivery and threatened patient safety. Based on semi-structured interviews with 27 healthcare professionals from 16 hospitals in the United States, this study explored perspectives of frontline clinicians regarding patient safety during the COVID-19 pandemic. Participants highlighted two main issues: (1) compromised access to health care and delayed diagnosis and treatment due to increasing telehealth use and deferred care and (2) impaired care delivery due to staffing and equipment shortages and space constraints, causing healthcare-associated infections, medication errors, and other patient safety events.