Engaging patients in their care can enhance safety, quality, and satisfaction. The Joint Commission and Centers for Medicare and Medicaid Services both call for health care organizations to encourage patient engagement in their care. This review and meta-analysis assessed which patient engagement strategies improve clinician adherence to recommended clinical practice. Two strategies had moderate impact: enhancing the information elicited from patients and educating patients about best clinical practice. Patient decision aids did not affect clinician performance, and the authors were unable to determine how interventions impacted health outcomes. A PSNet perspective explored novel avenues for patient engagement that leverage health information technology.