The unprecedented nature of the COVID-19 pandemic requires unique evaluation strategies to examine system responses to the pandemic and its effects on quality and patient safety. AHRQ will award $5 million in fiscal year 2020 to support novel, high-impact studies that evaluate the responsiveness of health care delivery systems, health care professionals, and the overall U.S. health care system in response to the COVID-19 pandemic. AHRQ expects to fund critical research focused on topics such as the effects on quality, safety, and value of the health system response to COVID-19; the role of primary care practices and professionals during the COVID-19 epidemic; understanding how the response to COVID-19 affected socially vulnerable populations and people with multiple chronic conditions; and the integration of digital health in the response to COVID-19, including innovations and challenges encountered in the expansion of telehealth. The process for submitting applications is now closed.