This AHRQ-supported study used a series of Patient Safety Indicators (PSIs) that were then applied to hospitals to characterize their safety profile. The selection of 20 specific PSIs for analysis resulted from choosing those amenable to capture from existing administrative data and with sensitivity to the quality of care. Investigators present their analyses and findings by sharing rates of potential patient safety events by age and sex, race and ethnicity, and hospital type (urban versus rural location and teaching status). The authors discuss the various approaches to evaluating inpatient safety and advocate for the low-cost method employed in this study, particularly as a guide to policymakers and other interested stakeholders.