This article describes the development of the Key Potentially Inappropriate Drugs in Pediatrics, or “KIDs” List, intended to create a standard of care for safe medication use in pediatric populations. A panel of seven pediatric pharmacists from the Pediatric Pharmacy Association developed an evidence-based list of candidate drugs which was then peer-reviewed and subjected to a public comment period. The final KIDs List includes 67 drugs/drug classes; most require a prescription and are available in various dosage formulations.