The authors systematically reviewed the evidence on electronic health record (EHR) interventions designed to improve the safety and quality of anticoagulation administration in inpatient hospitals settings. The 27 articles meeting inclusion criteria examined four types of interventions: computerized physician order entry (CPOE), clinical decision support systems (CDSS), dashboards, and general EHR implementation. Included studies reported reductions in medication errors and adverse drug events with use of CPOE and CDDS, but studies did not find benefits to other adverse events (e.g., bleeding events), readmissions or length of stay. Overall, the review found limited evidence demonstrating the benefit of inpatient EHR interventions in improving anticoagulation safety and quality.