Clinical decision support alerts can notify clinicians to potential prescribing errors and potentially avoid adverse drug events. This retrospective study evaluated over 16,000 alerts for drug-drug interactions and found that nearly 96% were overridden by providers; of these overrides, 45.4% were deemed appropriate upon chart review. Alerts for high-priority drug-drug interactions were overridden 87% of the time, and chart review determined that only 0.5% of these alerts were appropriate. The researchers found that 5.1 adverse drug events occurred per 100 overrides.