Healthcare-associated infections (HAI) can have detrimental results for patients and organizations. This study used HAI and financial data from nearly 1,500 acute care hospitals to assess the association between hospital financial performance and methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile (C. diff), catheter-associated urinary tract infections (CAUTI), and central line-associated bloodstream infections (CLABSI) infection rates. Each of the HAIs was positively associated with increased hospital costs, underscoring the importance of infection control policies to patient health and hospital financial health.