Hospitalized patients are routinely monitored by multiple electronic devices that alert clinical staff when readings exceed a specified range. Given the large number of devices, one patient may generate dozens of alerts per day, which contributes to alert fatigue. This review highlights alert fatigue in pediatric and neonatal hospital wards along with successful interventions to reduce alerts. Most alarms were associated with physiological monitoring. Only half of the studies included an intervention, the majority of which focused on changes to alarm parameters.