Efforts to address professionalism and individual accountability remain important in patient safety, even with the role systems play in poor patient outcomes. Past studies have tried to predict poor professional behavior based on medical school performance, and concerns have also been raised as a result of changes in residency training requirements. This article describes the efforts of one academic institution in teaching professionalism. The authors share their approach and model for addressing disruptive behavior, and their related interventions to prevent it. An AHRQ WebM&M conversation and commentary also discuss professionalism and patient safety.