Health information exchange (HIE) tools allow healthcare systems to electronically share patient information across different settings and can improve care coordination and communication. This study explored the facilitators and barriers to effective use of HIE tools for medication reconciliation among VA clinicians. The 63 participating clinicians shared facilitators encouraging HIE use, including familiarity with the software and confidence accessing necessary information. They also identified several barriers to HIE use, including information overload and lack of integration with other EHR interfaces.