Burnout has been a focus of numerous studies since the beginning of the COVID-19 pandemic; however, this is the first to focus on burnout and secondary traumatic stress (STS) among health system pharmacists. Nearly two thirds (65.3%) of respondents had a moderate to high likelihood of experiencing burnout and 51% had a high probability of STS. Due to the association between burnout and decreased patient safety, it is critical that health systems address pharmacist burnout appropriately.