Surgical site infections (SSIs) are a common source of preventable harm following surgery. In this retrospective claims-based study, researchers examined the impact of SSI infections after coronary artery bypass graft (CABG), bariatric surgery (BS), or certain orthopedic procedures. Findings indicate that patients with SSI infections had longer hospital stays, higher readmission rates, and higher medical costs compared to a matched cohort without SSI. Patients with SSI after orthopedic procedures had significantly higher 12-month mortality compared to patients without SSI.