Severe hospital-acquired pressure ulcers are considered a never event, and they result in loss of payment for the hospitalization according to Centers for Medicare and Medicaid Services (CMS) policy. Bundled interventions have shown success at preventing these complications in research studies, but broader data on their effectiveness have been lacking. This study used administrative data to demonstrate that adoption of evidence-based strategies and implementation of the CMS policy was associated with a decrease in the incidence of hospital-acquired pressure ulcers in academic medical centers.