The authors discuss the six interventions proposed by the 100,000 Lives Campaign and how these propose to improve the standard of care nationwide. The six campaign interventions are: Deploy Rapid Response Teams; Deliver Reliable Evidence-Based Care for Acute Myocardial Infarction; Prevent Adverse Drug Events Through Medication Reconciliation; Prevent Central-Line Infections; Prevent Surgical Site Infections; and Prevent Ventilator-Associated Pneumonia